Human physiology

Same mathematics, exploratory for now

We are open about the status of this: it is not a product line yet. It is where a series of side projects point, and it is likely to become real work in a year or two.

The mathematics does not change between a plant, a fish and a person. States, rates, controls, drivers, and a set of outcomes somebody cares about. What changes is which outcomes, and how much caution the conclusions deserve.

What already exists

Small, self-contained models built for their own sake, and because each one sharpened something in the framework:

  • Hormone pulses. How a hormone released in pulses produces a different effect than the same total dose given continuously, and what that implies for dosing. This connects to earlier academic work on pulsatile signalling.
  • Stress axis dynamics. The feedback loop that governs the cortisol response, and why recovery from a repeated stressor is not simply the mirror image of the response to it.
  • Thermoregulation under load. Heat balance for a person exercising: production, sweating, environment, and where the limits are.
  • Feeding rhythm and metabolism. Eating pattern rather than total intake, and what happens to reserves and substrate use across a day.

Why it matters for the other work

Two reasons, both practical. Physiology is where the observation problem is worst, because the measurements are expensive, sparse and indirect, so it is a hard test of the small-data approach. And the state-estimation work, running a model alongside a real individual and correcting it with each new measurement, is the same machinery as a digital twin of a greenhouse, tested on a system with much less patience.

If you work in this area and the approach sounds relevant, we would like to talk. It is the right moment for a collaboration, and the wrong moment for a product claim.

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